Frontal slow wave resting EEG power is higher in individuals at Ultra High Risk for psychosis than in healthy controls but is not associated with negative symptoms or functioning

M Sollychin; BN Jack; A Polari; A Ando; GP Amminger; C Markulev; PD McGorry; B Nelson; TJ Whitford; HP Yuen; S Lavoie

Journal article

Frontal slow wave resting EEG power is higher in individuals at Ultra High Risk for psychosis than in healthy controls but is not associated with negative symptoms or functioning

M Sollychin, BN Jack, A Polari, A Ando, GP Amminger, C Markulev, PD McGorry, B Nelson, TJ Whitford, HP Yuen, S Lavoie

Schizophrenia Research | ELSEVIER SCIENCE BV | Published : 2019

DOI: 10.1016/j.schres.2019.01.039

Abstract

Decreased brain activity in the frontal region, as indicated by increased slow wave EEG power measured by electrodes place on the skull over this area, in association with negative symptoms has previously been shown to distinguish ultra-high risk (UHR)individuals who later transitioned to psychosis (UHR-P)from those who did not transition (UHR-NP). The aims of the current study were to: 1)replicate these results and 2)investigate whether similar association between increased frontal slow wave activity and functioning shows any value in the prediction of transition to psychosis in UHR individuals. The brain activity, recorded using EEG, of 44 UHR individuals and 38 healthy controls was includ..

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University of Melbourne Researchers

Paul Amminger Author

Connie Markulev Author

Patrick McGorry Author

Barnaby Nelson Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

This work was supported by an Early Career Research grant from the University of Melbourne (SL) and a NARSAD grant (17537; TW). The Neurapro study was supported by grant 07TGF-1102 from the Stanley Medical Research Institute, grant 566529 from the NHMRC Australia Program and a grant from the Colonial Foundation. BN was supported by NARSAD Independent Investigator Grant from the Brain & Behavior Research Foundation (23199) and TW was supported by Career Development Fellowship from the NHMRC (APP1090507) and Discovery Projects from the ARC (DP140104394; DP170103094).